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Dr. Damon Wilkerson
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Dr. Sharon M. Tomaski, M.D.
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FOOD ALLERGIES
IN CHILDREN

An epidemic spiraling out of control

Written by JENNY DEAM

Ryan Clifford was 14 months old the first time he went into anaphylactic shock. The little boy’s grandmother was babysitting, and as she strapped him into his car seat, she noticed his nose was dripping furiously. She thought it curious, because he had no other sign of a cold. Within minutes, she checked the rear-view mirror and became panicked. Ryan’s face was so swollen and contorted he was all but unrecognizable. His tongue was lolling and he was gagging. His breath had turned ragged. She called her husband, a retired cardiologist, who told her to get him to a doctor as quickly as possible.

For four hours the doctor worked on him, pumping Ryan full of medicine and oxygen and watching for recovery. When Ryan’s parents, Dina and Bill Clifford, arrived at the doctor’s office, they had no idea what was happening to their son. “The doctor was so scared it scared us,” the boy’s mother remembers.

Later at home they found the culprit: a peanut butter and jelly sandwich with a toddler-sized nibble missing from one corner. Although Dina and Bill had no known history of food allergies in their family, it was terrifyingly obvious their son did. That day, their life as a family changed forever.

“It’s not what most people think of when you say ‘allergies’,” says Clifford, a 44-year-old business consultant from Centennial. “That day the doctor told me, ‘You’re going to have to be his advocate.’ I had no idea how challenging that would be.” Ryan was pulled out of his preschool after the doctor talked with its director, who worried the school did not fully understand the seriousness of Ryan’s medical condition. As a precaution, the Cliffords had their daughter, Carlee, tested a few years later, before she entered kindergarten. Her results showed allergy levels even higher than Ryan’s.

Life-threatening food allergies such as the peanut allergy Ryan and Carlee have are a modern medical mystery. Researchers find that over the past five years, the number of allergies in young children has doubled for reasons no one knows. In addition, some food allergies, such as dairy and wheat, that children once outgrew by the time they entered school, are now taking much longer to disappear, if they do at all.

Today, between 6 to 8 percent of children have a serious food allergy, says Dr. David Fleischer, an associate professor of pediatrics at National Jewish Medical and Research Center in Denver, and a lead investigator in a national five-year study into the causes and treatment of food allergies. Additionally, 50 to 80 percent of those children also will develop asthma. Again, no one knows why.

A leading theory among researchers is that the rise in food allergies may be caused by the so-called “hygiene hypothesis.” First introduced in the late 1980s, the theory surfaced to explain the increase in hay fever and asthma. The idea is that our society has become “cleaner” and healthier through the use of anti-bacterial cleaners and soaps in the home, as well as the routine use of antibiotics and immunizations in medicine. This, in turn, may be causing the immune systems in some children to fail to differentiate between real threats and harmless invaders, such as food. Some also believe that because immune systems are no longer fighting real threats, they overreact and shift to turn on the body’s own tissues.

Fleischer says the theory becomes more plausible as doctors find that the number of food allergies seems to be on the rise in developing nations, as they become more modernized. Another finding is an increase in food allergies as people from developing countries come to the United States. Fleischer had one patient whose parents came to the United States from India.

Neither parent had a history of food allergies, but their young son, born here, was diagnosed with severe food allergies. Again, it is not clear whether the blame comes from the way the food is processed in this country, how it is prepared or if it is some entirely, and as yet undetermined, different cause. It also is unknown why it strikes some children and not others.

Equally challenging is pinpointing exactly when these food allergies develop. Are children born with them, or do they develop in infancy and early childhood? Earlier in this decade, there was speculation that food allergies might start in the womb, so pregnant women were often cautioned against eating peanuts in late pregnancy. But a recent study in Great Britain seems to have disproved that theory, says Fleischer.

Because so much remains unknown about the causes of food allergies, misinformation flourishes. People sometimes believe they have food allergies when they do not. One recent study reported as much as 25 percent of Americans now believe they have a food allergy. Food aversions are often confused with allergies. And while the recent spotlight on the problem and headlines of fatal consequences have helped spread awareness, doctors like Fleischer now worry a climate of panic and misunderstanding has been created.

Even within the medical community, there is disagreement about diagnosis and treatment. Fleischer says the dangers are twofold: Patients who do not have severe food allergies are told they do and undergo the drastic lifestyle change it takes to manage one, or, perhaps more troubling, individuals with legitimate food allergies are dismissed or not treated properly.

Ellen Sanders, a stay-at-home mother of two in Highlands Ranch, knows well what can happen when a food allergy is treated cavalierly. Her youngest son, Aaron, 8, has a lifethreatening dairy allergy. Her older son, Christopher, 13, has none. Before Aaron entered kindergarten, she sought treatment from an alternative medical practice. They checked with their pediatrician, who was not opposed. The plan was to do a “food challenge,” whereby Aaron would be given a small amount of string cheese and ice cream to help build up a tolerance for dairy. They waited out the experiment for an hour without any adverse reaction. They left ecstatic.

Once home, though, Aaron complained of a terrible stomachache. Sanders thought his system was just unaccustomed to the new foods. Within minutes his body was covered in hives. She rushed him into the car to take him to the emergency room, located 10 minutes away. They didn’t make it. As she sped through her neighborhood, she kept talking to her son to keep him alert, but by then he had stopped talking. The color in his eyes had gone pale, and he was unresponsive. She pulled into a fire station, where a firefighter treated him for anaphylaxis and rushed him to the hospital. Sanders is haunted by what might have happened. But she says it also shows how parents will try anything in a desperate search for normalcy for their children.

Both Sanders and Clifford say theirs is an ongoing struggle with the outside world. Many think they are neurotic parents. Even other family members do not always fully believe the severity of the situation because food allergies were largely unheard of a generation ago. Sanders ultimately pulled her son out of his school and now home schools him to avoid struggles with teachers and other parents to make them understand the dangers her son faces. Clifford has developed a business selling plastic flashcards called “Beyond a Peanut,” a teaching tool for schools, babysitters and other parents, to help them better understand the hidden risks and behaviors that must be avoided.

What many don’t grasp, both mothers say, are the dangers of cross-contamination, whereby a classmate who has eaten a peanut or dairy product has the residue on his or her hands. If they then touch an allergic child who in turn puts his hand in his mouth or wipes his nose, a reaction can occur. Or not.

The parents say one of the most agonizing things in their world is its unpredictability. Ryan Clifford is now 5 and will soon enter kindergarten. A bright boy with an impish smile and vibrant imagination, he has invented a private fantasy where he loads his stuffed animals into a rocket ship and leaves for a planet where there are no peanuts. There, he says, he can be like all the other kids.